The Changing Role of the Clinical Microbiology Laboratory in Defining Resistance in Gram-negatives

• Autores: Andrea Endimiani, Michael R. Jacobs
• Localización: Infectious disease clinics of North America, ISSN 0891-5520, Vol. 30, Nº. 2, 2016 (Ejemplar dedicado a: Antibiotic Resistance: Challenges and Opportunities), págs. 323-345
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • The evolution of resistance in Gram-negatives has challenged the clinical microbiology laboratory to implement new methods for their detection. Multidrug-resistant strains present major challenges to conventional and new detection methods. More rapid pathogen identification and antimicrobial susceptibility testing have been developed for use directly on specimens, including fluorescence in situ hybridization tests, automated polymerase chain reaction systems, microarrays, mass spectroscopy, next-generation sequencing, and microfluidics. Review of these methods shows the advances that have been made in rapid detection of resistance in cultures, but limited progress in direct detection from specimens.