Resumen de Association of Toll-like receptors 2, 3, and 4 genes polymorphisms with periapical pathosis risk

Ülkü Özan, Zeynep Ocak, Fatih Özan, Elif-Aybala Oktay, Orçun Toptaş, Halil Sahman, İhsan Yikilgan, Hasan Orucoglu, Kürşat Er

• Background: The aim of this study was to investigate the role of gene variations of Toll-like receptors (TLR) 2, 3, and 4 on genetic susceptibility to periapical pathosis.

  Material and Methods: One hundred patients were included in the study and divided into two groups as follows;

  Control Group (n=50) that have root canal treatment and no periapical lesion, Patient Group (n=50) that have root canal treatment and periapical lesion. TLR2 Arg753Gln, TLR3 (c.1377C/T) and TLR4 Asp299Gly and Thr399Ile polymorphisms were genotyped by using PCR-RFLP. Genotypical analysis of control and patient groups were investigated to disclose whether there is any association between periapical lesions and gene variations.

  Results: There are no significant statistical differences between control and patient groups according to TLR 2 and 4 gene sequence. On the contrary, CC allele detected 74% for TLR 3 in patient group, and this difference was found to be statistically significant ( p < 0.005).

  Conclusions: According to these results, it can be suggested that patients with Toll-like receptor 3 gene polymorphisms could be susceptible to periapical pathosis.