Cryptococcosis

• Autores: Eileen K. Maziarz, J. R. Perfect
• Localización: Infectious disease clinics of North America, ISSN 0891-5520, Vol. 30, Nº. 1, 2016 (Ejemplar dedicado a: Fungal Infections), págs. 179-206
• Idioma: inglés
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• Resumen

  • Cryptococcosis is an invasive mycosis caused by pathogenic encapsulated yeasts in the genus Cryptococcus. Cryptococcus gained prominence as a pathogen capable of widespread disease outbreaks in vulnerable populations. We have gained insight into the pathobiology of Cryptococcus, including the yeast' s capacity to adapt to environmental pressures, exploit new geographic environments, and cause disease in both immunocompromised and apparently immunocompetent hosts. Inexpensive, point-of-care testing makes diagnosis more feasible than ever. The associated worldwide burden and mortality remains unacceptably high. Novel screening strategies and preemptive therapy offer promise at making a sustained and much needed impact on this sugar-coated opportunistic mycosis.