S-l combined with cisplatin plus concurrent chemoradiotherapy versus cisplatin plus concurrent chemoradiotherapy for Chinese patients with advanced gastric cancer: a multi-centre randomized controlled trial

• X. Chen ^[1] ; W. Li ^[2] ; L. Sun ^[2] ; Y. Liu ^[2] ; S. Liu ^[2] ; R. Ma ^[2]
  1. [1] Fourth Affiliated Hospital of Harbin Medical University

     Fourth Affiliated Hospital of Harbin Medical University

     China

     
  2. [2] The Third Affiliated Hospital of Harbin Medical University

     The Third Affiliated Hospital of Harbin Medical University

     China

     
• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 18, Nº. 7, 2016, págs. 672-676
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Background This study aimed to investigate the safety and efficacy of S-l combined with cisplatin plus concurrent chemoradiotherapy (SCCC) versus cisplatin plus concurrent chemoradiotherapy (CCC) for Chinese patients with advanced gastric cancer (AGC).

    Methods Between April 2008 and June 2010, 144 eligible patients with AGC were included and divided randomly into 2 groups. Seventy-two patients in the SCCC group received with S-1 on days 1–14 of a 21-day cycle, 24-h cisplatin infusion (70 mg/m2 on day 1) every 4 weeks for 2 cycles, and concurrent chemoradiotherapy (30-Gy radiotherapy over 4 weeks) beginning on day 1. The other 72 patients in the CCC group were administered cisplatin and concurrent chemoradiotherapy as for SCCC. The primary outcome was overall survival. Secondary outcomes were progression-free survival and adverse events.

    Results The median overall survival durations were 11.7 months (range 1.7–29.7 months) and 9.5 months (range 1.2–25.4 months) in SCCC and CCC groups, respectively (P = 0.041). The median progression-free survival durations were 10.6 months for SCCC (range 1.3–24.7 months) and 8.8 months (range 0.7–22.3 months) for CCC (P = 0.046). The toxicity profile was similar in both groups.

    Conclusion In summary, SCCC showed more promising safety and efficacy than CCC in Chinese patients with AGC. In addition, the toxicities were also acceptable in both groups.