Anticancer Activity of Estradiol Derivatives: A Quantitative Structure-Activity Relationship Approach

• Ken Muranaka ^[1]
  1. [1] K''s Garden Nishioji, Japan
• Localización: Journal of chemical education, ISSN 0021-9584, Vol. 78, Nº 10, 2001, pág. 1390
• Idioma: inglés
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• Resumen

  • Commercial packages to implement modern QSAR (quantitative structure-activity relationship) techniques are highly priced; however, the essence of QSAR can be taught without them. Microsoft Excel was used to analyze published data on anticancer activities of estradiol analogs by a QSAR approach. The resulting QSAR equations highly correlate the structural features and physicochemical properties of the analogs with the observed biological activities by multiple linear regression.