Menopausal Women Have Hypofibrinolysis Even in Subclinical Stage of Atherosclerosis

• Autores: Nydia Córdova Pérez, Lourdes Basurto Acevedo, José Antonio Degollado Córdova, Renata Patricia Saucedo García, Carlos Martínez Murillo, Arturo Zárate Treviño, Ana Laura Vázquez Martínez, Sara Vega García, Alma Grisel Díaz Martínez, Gabriela Borrayo Sánchez, Elba Reyes Maldonado
• Localización: Revista de investigación clínica, ISSN 0034-8376, ISSN-e 2564-8896, Vol. 67, Nº. 2, 2015, págs. 122-129
• Idioma: inglés
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• Resumen

  • Background: PAI-1 is the main inhibitor of fibrinolysis. Increase in PAI-1 levels has been associated with the risk of coronary disease; however, there are few studies on the relationship between subclinical atherosclerosis and PAI-1 levels. Objective: The aim of this study was to analyze the relationship between PAI-1 level and carotid intima-media thickness in premenopausal and postmenopausal women without apparent cardiovascular disease. Material and Methods: A cross-sectional study was conducted in 142 women aged 45 to 60 years with no history of cardiovascular disease. Anthropometric and laboratory measurements were performed, including PAI-1 levels. All participants underwent a B-Mode ultrasound to measure intima-media thickness.

    Subclinical atherosclerosis was considered when intima-media thickness was ≥ 0.7 mm and/or an atheromatous plaque was observed. Results: Postmenopausal women had greater intima-media thickness than premenopausal women (0.688 ± 0.129 vs.

    0.621 ± 0.113 mm; p < 0.05). Compared to women with normal intima-media thickness, women with subclinical atherosclerosis had higher PAI-1 levels (23.2 ± 13.7 vs. 30.4 ± 20.7 ng/ml; p < 0.05). In all participants, intima-media thickness correlated with PAI-1 (r = 0.302; p = 0.01) and with age (r = 0.358; p = 0001). Conclusions: An increase in intima-media thickness was observed in postmenopausal women compared with premenopausal women. Asymptomatic women with increased intima-media thickness had higher PAI-1 levels. These findings suggest that fibrinolytic activity is low in the subclinical stage of atherosclerosis.

    (REV INVES CLIN. 2015;67:122-9) Corresponding author: Lourdes Basurto, lbasurtoa@yahoo.com