New Diagnostics for Childhood Tuberculosis

• Autores: Silvia S. Chiang, Douglas S. Swanson, Jeffrey R. Starke
• Localización: Infectious disease clinics of North America, ISSN 0891-5520, Vol. 29, Nº. 3, 2015 (Ejemplar dedicado a: Pediatric Infectious Disease: Part I), págs. 477-502
• Idioma: inglés
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• Resumen

  • The challenge of diagnosing childhood tuberculosis (TB) results from its paucibacillary nature and the difficulties of sputum collection in children. Mycobacterial culture, the diagnostic gold standard, provides microbiological confirmation in only 30% to 40% of childhood pulmonary TB cases and takes up to 6 weeks to result. Conventional drug susceptibility testing requires an additional 2 to 4 weeks after culture confirmation. In response to the low sensitivity and long wait time of the traditional diagnostic approach, many new assays have been developed. These new tools have shortened time to result; however, none of them offer greater sensitivity than culture.