In 2009, Hans Clevers and Toshiro Sato (then a postdoc in Clevers' lab) demonstrated a powerful new model to study development and disease: a three-dimensional 'organoid' derived from adult stem cells that replicates the structure of cells lining the intestine. More than 100 labs worldwide are now working with different types of organoid to study cancer and other diseases. Clevers, at the Hubrecht Institute in Utrecht, the Netherlands, discusses the potential of this approach.
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