Microcirculation and hemorheology
-
Aleksander S. Popel [1] ; Paul C. Johnson [2]
-
[1] Johns Hopkins University
Johns Hopkins University
Estados Unidos
-
[2] University of California, San Diego
University of California, San Diego
Estados Unidos
-
- Localización: Annual review of fluid mechanics, ISSN 0066-4189, Nº. 37, 2005, págs. 43-69
- Idioma: inglés
- Texto completo no disponible (Saber más ...)
-
Resumen
We review major experimental and theoretical studies on microcirculation and hemorheology, focusing on mechanics of blood flow and the vascular wall. We discuss flow of the blood formed elements [red blood cells (RBCs), white blood cells or leukocytes (WBCs) and platelets] in individual arterioles, capillaries, and venules, and in microvascular networks. We also review mechanical and rheological properties of the formed elements and their interactions with the vascular wall. We discuss short-term and long-term regulation of the microvasculature; the modes of regulation include metabolic, myogenic, and shear-stress-dependent mechanisms as well as vascular adaptation such as angiogenesis and vascular remodeling.
