Reducing Dental Plaque and Gingivitis With 0.6% Cortex Ilicis Rotundae Toothpaste: A Randomized, Double-Masked Clinical Trial
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Hongchun Liu [1] ; Wei Yin [2]
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[1] Sun Yat-sen University
Sun Yat-sen University
China
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[2] Sichuan University
Sichuan University
China
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- Localización: Journal of periodontology, ISSN 0022-3492, Vol. 87, Nº. 3, 2016, págs. 327-333
- Idioma: inglés
- Enlaces
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Resumen
Background: Cortex Ilicis Rotundae has antioxidant and anti-inflammatory properties. Few studies have evaluated the effects of toothpastes containing Cortex Ilicis Rotundae. This study evaluates the antiplaque and antigingivitis effects of a test toothpaste containing 0.6% Cortex Ilicis Rotundae extract in a calcium carbonate base compared with a control toothpaste without any active ingredient.
Methods: One hundred adults with a mean plaque index (PI) ≥1.5 and a mean gingival index (GI) ≥1.0 were enrolled in this randomized, double-masked, placebo-controlled clinical trial. They were assigned randomly to use a test toothpaste or a control toothpaste. At baseline, 6 weeks, and 12 weeks, they received examinations of oral hard and soft tissues, using Löe-Silness GI for gingivitis and the Turesky modification of the Quigley-Hein PI for PI. Adverse events were monitored.
Results: When the study was completed, the test group reported lower mean GI than the control group (1.13 ± 0.22 versus 1.30 ± 0.23; P = 0.001) and lower mean PI than the control group (2.53 ± 0.5 versus 2.93 ± 0.44; P <0.001). Compared to the baseline, the test group had reductions in GI and PI of 14.39% and 17.86%, respectively (both P <0.001); the control group had reductions in GI and PI of 3.7% and 3.93%, respectively (both P <0.001). No adverse events were reported during the course of the study.
Conclusion: The toothpaste containing 0.6% Cortex Ilicis Rotundae was effective in reducing dental plaque and gingivitis after 12 weeks of use compared with a negative control toothpaste.
