Treatment of Clostridium difficile Infections

• Autores: Melinda M. Soriano, Stuart Johnson
• Localización: Infectious disease clinics of North America, ISSN 0891-5520, Vol. 29, Nº. 1, 2015 (Ejemplar dedicado a: Clostridium difficile Infection), págs. 93-108
• Idioma: inglés
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• Resumen

  • Vancomycin and metronidazole were historically considered equivalent therapies for the management of Clostridium difficile infections (CDI); however, recent data confirm more favorable outcomes with vancomycin. Fidaxomicin is a narrow spectrum antibiotic that has an advantage in reducing recurrence rates compared with vancomycin, possibly owing to its sparing effect on normal colonic microbiota. Data are limited for guiding management of CDI recurrences, particularly multiple recurrences. Several empiric approaches to manage these cases are reviewed.