The Prospect for Vaccines to Prevent Clostridium difficile Infection

• Autores: Chandrabali Ghose
• Localización: Infectious disease clinics of North America, ISSN 0891-5520, Vol. 29, Nº. 1, 2015 (Ejemplar dedicado a: Clostridium difficile Infection), págs. 145-162
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Clostridium difficile is a spore-forming anaerobic gram-positive organism that is the leading cause of antibiotic-associated nosocomial infectious diarrhea in the Western world. This article describes the evolving epidemiology of C difficile infection (CDI) in the twenty-first century, evaluates the importance of vaccines against the disease, and defines the roles of both innate and adaptive host immune responses in CDI. The effects of passive immunotherapy and active vaccination against CDI in both humans and animals are also discussed