Efficacy and safety of a dietary supplement containing a lipid co-extract from Serenoa repens and Pygeum africanum for the treatment of androgenetic alopecia (AGA) in women: Results of a randomized, double-blind, placebo-controlled clinical trial

• Josep Maria Borrás ^[2] ; Núria Piqué ^[1] ; Carlos Nieto ^[2] ; Jordi González ^[2]
  1. [1] Universitat de Barcelona

     Universitat de Barcelona

     Barcelona, España

     
  2. [2] Reig Jofre Group, S.A. Barcelona, España
• Localización: Más dermatología, ISSN 1887-5181, Nº. 25, 2016, págs. 5-14
• Idioma: inglés
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• Dialnet Métricas: 1 Cita
• Resumen

  • Background: Few clinical trials have assessed the usefulness of Serenoa repens and Pygeum africanum for the treatment of androgenetic alopecia (AGA).

    Purpose: To assess the efficacy of a dietary supplement (RJ-SP4AGA) containing a lipid co-extract from Serenoa repens and Pygeum africanum in post-menopausal women with AGA.

    Methods: A randomized, double-blind, placebo-controlled clinical trial was performed in post-menopausal women with AGA, who received RJ-SP4AGA capsules or placebo capsules (two capsules/day during 16 weeks). At baseline, after 8 and 16 weeks, a phototrichogram analysis (anagen and telogen hair), a pull test (hair resistance to traction) and tolerability assessments were performed.

    Results: A total of 40 Caucasian women were included, with a mean age of 58 years. After 16 weeks of treatment with RJ-SP4AGA capsules, anagen hair significantly increased and telogen hair significantly decreased (as mean %), with significant differences in comparison with placebo (p< 0.001). Hair resistance to traction also increased after 8 and 16 weeks in both groups. The RJ-SP4AGA capsules were well tolerated during treatment.

    Conclusions: The dietary supplement RJ-SP4AGA capsules is useful in reverting the signs of AGA in post-menopausal women.