Two well-defined new species of Iresine from Mexico are described based on character data covering vegetative and floral morphology, pollen, and sequences of plastid matK-trnK, trnL-F and rpl16 as well as nuclear ITS. We provide morphological and molecular descriptions, as well as a discussion on diagnostic characters and taxonomic affinities. Both species are distributed in cloud forests; I. borschii is known only from two collections in Veracruz, whereas I. sousae has been collected several times in Oaxaca and Chiapas. Both species are illustrated from herbarium specimens to facilitate their recognition. New field collections and observations are needed to improve our knowledge on the habitat and conservation status of these new species.
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