Combinatorial Synthesis and Discovery of an Antibiotic Compound. An Experiment Suitable for High School and Undergraduate Laboratories

• Scott E. Wolkenberg ^[1] ; Andrew I. Su ^[1]
  1. [1] Scripps Research Institute

     Scripps Research Institute

     Estados Unidos

     
• Localización: Journal of chemical education, ISSN 0021-9584, Vol. 78, Nº 6, 2001, pág. 784
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • An exercise demonstrating solution-phase combinatorial chemistry and its application to drug discovery is described. The experiment involves the synthesis of six libraries of three hydrazones, screening the libraries for antibiotic activity, and deconvolution to determine the active individual compound. The laboratory was designed for a high school classroom, though it can easily be expanded to suit a college introductory organic laboratory course.