For many medications, the pharmacokinetics and pharmacodynamics in pets have not been established and even where studies have been done, there is widespread species and individual variation. Practitioners should start with the lower end of the dose range and titrate up to maximum doses where there is insufficient therapeutic effect and no adverse effects or contraindications. Complete blood count, serum chemistry profile, and urinalysis should be performed before initiating the use of any medication, especially with off-label medications. Pharmacologic intervention for the treatment of behavior problems should be considered just one aspect of a comprehensive behavioral management and treatment protocol.
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