Pharmacogenomic agreement between two cancer cell line data sets

• Autores: Nicolas Stransky, Mahmoud Ghandi, Gregory V. Kryukov
• Localización: Nature: International weekly journal of science, ISSN 0028-0836, Vol. 528, Nº 7580, 2015, págs. 84-87
• Idioma: inglés
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• Resumen

  • Large cancer cell line collections broadly capture the genomic diversity of human cancers and provide valuable insight into anti-cancer drug response. Here we show substantial agreement and biological consilience between drug sensitivity measurements and their associated genomic predictors from two publicly available large-scale pharmacogenomics resources: The Cancer Cell Line Encyclopedia and the Genomics of Drug Sensitivity in Cancer databases.