Resumen de A Hydrazine-Free Wolff–Kishner Reaction Suitable for an Undergraduate Laboratory
Philippa B. Cranwell, Andrew T. Russell
A Wolff–Kishner reaction that does not require hydrazine has been developed. The reaction sequence has two steps: formation of a carbomethoxyhydrazone from methyl hydrazinocarboxylate and acetophenone, then decomposition of this intermediate by treatment with potassium hydroxide in triethylene glycol. Purification is by filtration through a plug of silica encased in the barrel of a plastic syringe. The reaction sequence can be completed within a day-long laboratory class (8 h).
