An Indexed Combinatorial Library: The Synthesis and Testing of Insect Repellents

• Autores: William H. Miles, Kathy A. Gelato, Kristen M. Pompizzi, Aislinn M. Scarbinsky, Brian K. Albrecht, Elaine R. Reynolds
• Localización: Journal of chemical education, ISSN 0021-9584, Vol. 78, Nº 4, 2001, pág. 540
• Idioma: inglés
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• Resumen

  • An indexed combinatorial library of amides was prepared by the reaction of amines and acid chlorides. A simple test for insect repellency using fruit flies (Drosophila melanogaster) allowed the determination of the most repellent sublibraries. The student-generated data were collected and analyzed to determine the most active amide(s) in the library. This experiment illustrates the fundamentals of combinatorial chemistry, a field that has undergone explosive growth in the last decade.