Association Between Comorbidity Burden and Rapid Cognitive Decline in Individuals with Mild to Moderate Alzheimer's Disease

• Autores: Lauren Aubert, Sophie Pichierri, Caroline Hommet, Vincent Camus, Gilles Berrut, Laure de Decker
• Localización: Journal of the American Geriatrics Society, ISSN 0002-8614, Vol. 63, Nº. 3, 2015, págs. 543-547
• Idioma: inglés
• Enlaces
  • Texto completo
• Resumen

  • Objectives To determine the association between rapid cognitive decline and burden of comorbidities as assessed using the Charlson Comorbidity Index in individuals aged 65 and older with Alzheimer's disease (AD).

    Design Retrospective cohort study.

    Setting Memory clinic at the University Hospital of Nantes.

    Participants Individuals aged 65 and older with AD (n = 170).

    Measurements Subjects were followed for 1 year. Rapid cognitive decline was defined as a decrease of 3 or more points on the Mini-Mental State Examination per 12-month period. Variables studied were the Charlson Comorbidity Index (measure of comorbidity burden), age, sex, AD stage, type of residence (living at home or not), presence of caregiver, functional abilities (Lawton and Katz scales), risk of malnutrition or depression, and intercurrent events (hospitalization or initiating home care).

    Results Rapid cognitive decline at 1-year follow-up occurred in 65 subjects (38.2%). In fully adjusted logistic regression analysis, Charlson Comorbidity Index was significantly associated with rapid cognitive decline (odds ratio (OR) = 1.30, P = .03). Moderate stage of AD (OR = 2.07, P = .04) and living at home (OR = 4.17, P = .04) were also associated with rapid cognitive decline.

    Conclusion Comorbidity burden was associated with rapid cognitive decline in subjects with AD.