Flutemetamol (18F): a β-amyloid positron emission tomography tracer for Alzheimer's and dementia diagnosis.

• Autores: Jane de Lartigue
• Localización: Medicamentos de actualidad = Drugs of today, ISSN 1699-3993, Vol. 50, Nº. 3, 2014, págs. 219-230
• Idioma: inglés
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• Resumen

  • Alzheimer's disease (AD) is a progressive, neurodegenerative disease likely to dramatically increase in prevalence in the next few decades. Currently, the only method for definitive diagnosis is to determine the presence of beta-amyloid in the brain of AD patients at autopsy. Flutemetamol (18F) (Vizamyl) is a novel 18F-labeled radiotracer for positron emission tomography (PET). Flutemetamol (18F) displays similar metabolism and dosimetry to the established amyloid PET imaging tracer 11C-labeled Pittsburgh Compound B and other 18F-labeled radiopharmaceuticals, and is rapidly taken up into the brain and binds to beta-amyloid deposits. Scans can be reliably quantified by the use of relative standard uptake value ratios, using the cerebellar cortex as a reference region. High sensitivity and specificity were demonstrated in phase III trials in discriminating between patients with AD and healthy controls and across a spectrum of AD, leading to the agent's approval to assist in the assessment of amyloid plaque pathology in AD patients.