Finding a Cure for Human Immunodeficiency Virus-1 Infection

• Autores: Joel N. Blankson, Janet D. Siliciano, Robert F. Siliciano
• Localización: Infectious disease clinics of North America, ISSN 0891-5520, Vol. 28, Nº. 4, 2014 (Ejemplar dedicado a: Updates in HIV and AIDS: Part II), págs. 633-650
• Idioma: inglés
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• Resumen

  • Remarkable advances have been made in the treatment of human immunodeficiency virus (HIV)-1 infection, but in the entire history of the epidemic, only 1 patient has been cured. Herein we review the fundamental mechanisms that render HIV-1 infection difficult to cure and then discuss recent clinical and experimental situations in which some form of cure has been achieved. Finally, we consider approaches that are currently being taken to develop a general cure for HIV-1 infection.