Current Status and Prospects for a Helicobacter pylori Vaccine

• Autores: Thomas G. Blanchard, Steven J. Czinn
• Localización: Gastroenterology clinics of North America, ISSN 0889-8553, Vol. 44, Nº. 3, 2015 (Ejemplar dedicado a: Management of Helicobacter pylori–Related Diseases), págs. 677-689
• Idioma: inglés
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• Resumen

  • Helicobacter pylori infection contributes to a variety of gastric diseases. H pylori-associated gastric cancer is diagnosed in advanced stages, and a vaccine against H pylori is desirable in parts of the world where gastric cancer remains a common form of cancer. Some of the strategies of vaccine development used in animals have been tested in several phase 3 clinical trials; these trials have been largely unsuccessful, although H pylori-specific immune responses have been induced. New insights into promoting immunity and overcoming the immunosuppressive nature of H pylori infection are required to improve the efficacy of an H pylori vaccine.