ABC transporters in the protozoan parasite Leishmania

• José M. Pérez-Victoria ^[1] ; Adriana Parodi-Talice ^[1] ; Cristina Torres ^[1] ; Francisco Gamarro ^[1] ; Santiago Castanys ^[1]
  1. [1] Instituto de Parasitología y Biomedicina López Neyra

     Instituto de Parasitología y Biomedicina López Neyra

     Armilla, España

     
• Localización: International microbiology: official journal of the Spanish Society for Microbiology, ISSN 1139-6709, Vol. 4, Nº. 3, 2001, págs. 159-166
• Idioma: inglés
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• Resumen

  • ATP-binding cassette ABC) transporters constitute one of the biggest and most conserved protein families in the evolutionary scale. Many of them are of enormous clinical relevance, due to their relationship with genetic diseases and drug resistance during the treatment of cancer and infectious diseases. Leishmaniasis is a major and globally widespread group of parasitic diseases, whose treatment has been complicated by the expansion of resistance to conventional drugs. Here, we review the current knowledge about ABC transporters in Leishmania spp, with special attention to their relationship with the drug-resistance phenotype.