Eosinophilic Esophagitis: Historical Perspective on an Evolving Disease

• Autores: Stephen E. Attwood, Glenn T. Furuta
• Localización: Gastroenterology clinics of North America, ISSN 0889-8553, Vol. 43, Nº. 2, 2014 (Ejemplar dedicado a: Eosinophilic Esophagitis), págs. 185-199
• Idioma: inglés
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• Resumen

  • Initial case series describing children and adults with symptoms related to esophageal dysfunction and dense esophageal eosinophilia lead to recognition of a “new” disease, eosinophilic esophagitis (EoE). Clinical, basic, and translational studies have provided a deeper understanding of this somewhat enigmatic disease that mechanistically is defined as an antigen-driven condition limited to the esophagus. This article summarizes many of the key historical features of EoE and provides a glimpse of potential future developments.