Forensic Investigation of Methadone Concentrations in Deceased Breastfed Infants

• Parvaz Madadi ^[2] ; Lauren E. Kelly ^[3] ; Colin J. Ross ^[1] ; Charis Kepron ^[4] ; James N. Edwards ^[5] ; Gideon Koren ^[3]
  1. [1] University of British Columbia

     University of British Columbia

     Canadá

     
  2. [2] Centre of Forensic Sciences Toxicology Section Toronto ON Canada
  3. [3] Western University.Canada
  4. [4] Ontario Forensic Pathology Service Ottawa ON Canada
  5. [5] Office of the Chief Coroner of Ontario Toronto ON Canada

  Mostrar afiliaciones +
• Localización: Journal of forensic sciences, ISSN-e 1556-4029, ISSN 0022-1198, Vol. 61, Nº. 2, 2016, págs. 576-580
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • There is a paucity of data to aid in assessing whether postmortem methadone findings in breastfed infants are clinically and/or toxicologically significant. Two cases are reported in which methadone was detected in deceased neonates whose mothers were enrolled in methadone maintenance programs and were breastfeeding. In addition to a complete autopsy and toxicological testing for alcohol, prescription medications, and drugs of abuse, pharmacogenetic analysis was performed for variants in genes related to methadone metabolism and response. In both cases, the postmortem methadone concentration measured in neonatal heart blood was higher than the maximum serum methadone con- centration reported in living breastfed infants whose mothers were receiving methadone. However, additional analysis of antemortem blood indicated postmortem redistribution of methadone. Pharmacogenetic results were suggestive of a potential predisposition to methadone toxicity based on studies in adults; the significance of these findings in breastfed neonates requires further research. The medical cause of death was unascertained in both cases