Physiologic and biochemical effects of electroacupuncture combined with intramuscular administration of dexmedetomidine to provide analgesia in goats

• Zahir ^[7] ; Man ^[1] ; Zheng ^[2] ; Jie ^[3] ; Juan ^[8] ; Shao ^[4] ; Wei ^[5] ; Ming ^[6]
  1. [1] L. Hu
  2. [2] Y. Qiu Zhou
  3. [3] Zeng
  4. [4] W. Wang
  5. [5] Zhang
  6. [6] X. Ding
  7. [7] Shah
  8. [8] Wan

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• Localización: American Journal of Veterinary Research, ISSN-e 1943-5681, ISSN 0002-9645, Vol. 77, Nº. 3, 2016, págs. 252-259
• Idioma: inglés
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  • Physiologic and biochemical effects of electroacupuncture combined with intramuscular administration of dexmedetomidine to provide analgesia in goats Zahir Shah, MS; Man L. Hu, MS; Zheng Y. Qiu, MS; Fei Y. Zhou, BS; Jie Zeng, BS; Juan Wan, BS; Shao W. Wang, BS; Wei Zhang, BS; Ming X. Ding, PhD Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, People's Republic of China. (Shah, Hu, Qiu, Zhou, Zeng, Wan, Wang, Zhang, Ding) The first 2 authors contributed equally to the work.

    Address correspondence to Dr. Ding (dmx@mail.hzau.edu.cn).

    OBJECTIVE To investigate physiologic and biochemical effects of electroacupuncture and dexmedetomidine administration to goats.

    ANIMALS 30 healthy adult goats.

    PROCEDURES Goats were allotted to 5 groups (6 goats/group) and received electroacupuncture, dexmedetomidine (5 or 20 μg/kg, IM), electroacupuncture plus dexmedetomidine (5 μg/kg, IM), or saline (0.9% NaCl) solution (IM [control treatment]). Pain threshold, cardiorespiratory effects, rectal temperature, and hematologic and biochemical variables were assessed.

    RESULTS Dexmedetomidine (20 μg/kg) increased pain threshold and decreased heart rate, respiratory rate, and rectal temperature. Pain threshold of goats receiving electroacupuncture plus dexmedetomidine (5 μg/kg) was higher than that of goats receiving electroacupuncture or of goats receiving dexmedetomidine at 5 μg/kg at 30 minutes, but did not differ from that of goats receiving dexmedetomidine at 20 μg/kg. Compared with goats administered dexmedetomidine at 20 μg/kg, goats receiving electroacupuncture plus dexmedetomidine at 5 μg/kg had a higher heart rate from 30 to 60 minutes and a higher respiratory rate from 5 to 60 minutes. Electroacupuncture plus dexmedetomidine (5 μg/kg) did not affect rectal temperature. Serum glucose concentrations of goats receiving electroacupuncture plus dexmedetomidine (5 μg/kg) were higher than for goats receiving dexmedetomidine at 5 μg/kg at 30 minutes but not for goats receiving dexmedetomidine at 20 μg/kg. Creatinine and BUN concentrations, alanine or aspartate aminotransferase activities, and hematologic variables of treated goats did not change.

    CONCLUSIONS AND CLINICAL RELEVANCE Electroacupuncture in combination with a low dose of dexmedetomidine (5 μg/kg, IM) administered to goats provided antinociception.