The unexpected side effects and safety of therapeutic monoclonal antibodies.

• Autores: C. L. Liu, A. Y. Li
• Localización: Medicamentos de actualidad = Drugs of today, ISSN 1699-3993, Vol. 50, Nº. 1, 2014, págs. 33-50
• Idioma: inglés
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• Resumen

  • Monoclonal antibodies (MAbs) have ushered in a new era of targeted therapy, particularly in the fields of immunotherapy and oncology. MAbs have been developed from murine antibodies to fully human antibodies, with significant improvements in immunogenicity and safety. Nevertheless, the safety of these agents is being paid close attention with relative side effects being reported. These side effects have caused many researchers' confidence in MAbs to waver. This review comprehensively summarizes the side effects of MAbs in clinical use, highlighting the prevention and management of adverse effects. Although many MAbs are well tolerated, with new MAbs continuing to be innovated, it is hard to ensure that every fresh stock of MAbs is absolutely safe. The clinical use of MAbs will face greater challenges in the future. Physicians should be on the alert for lethal side effects and treat them as soon as possible.