Inflammatory Mechanisms in Hidradenitis Suppurativa

• Autores: G. Kelly, Errol P. Prens
• Localización: Dermatologic clinics, ISSN 0733-8635, Vol. 34, Nº. 1, 2016 (Ejemplar dedicado a: Hidradenitis Suppurativa), págs. 51-58
• Idioma: inglés
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• Resumen

  • Hidradenitis suppurativa (HS) is a chronic relapsing disease of follicular occlusion that causes immense clinical and psychosocial morbidity when refractory to treatment. HS is no longer considered a disease of primary infectious etiology, although bacteria play a role. There is increasing evidence that HS is associated with immune dysregulation, based on its clinical association with other immune-mediated disorders, by its response to biologic therapy in the clinical arena, and from molecular research. This article summarizes what is known in relation to the inflammatory pathways in HS.