Endocrinologic Aspects of Hidradenitis Suppurativa

• Autores: Ioannis Karagiannidis, Georgios Nikolakis, Christos C. Zouboulis
• Localización: Dermatologic clinics, ISSN 0733-8635, Vol. 34, Nº. 1, 2016 (Ejemplar dedicado a: Hidradenitis Suppurativa), págs. 45-49
• Idioma: inglés
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• Resumen

  • Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder of unknown etiology. The role of hormones in HS remains unclear, but the observation of premenstrual flares, female predominance, and improvement during pregnancy suggest a hormonal/metabolic background. The reported positive effects of antiandrogen therapy supports a possible role of androgens. The predominant onset of the disease years after puberty may indicate a metabolic disorder. Obesity contributes significantly to HS pathogenesis; diabetes, dyslipidemia, the metabolic syndrome, and polycystic ovarian syndrome are among the commonest comorbidities. More studies are required to clarify a potential hormonal dysregulation in HS.