Fasting Plasma Glucose at 24-28 Weeks to Screen for Gestational Diabetes Mellitus:: New evidence from China

• Autores: Wei-wei Zhu, Ling Fan, Hui-xia Yang, Ling Ying Kong, Shi ping Su, Zi-lian Wang, Ya Li Hu, Mei-hua Zhang, Li Zhou Sun, Yang Mi, Xiu Ping Du, Hua Zhang, Yun-hui Wang, Yin Ping Huang, Li-ruo Zhong, Hai-rong Wu, Nan Li, Yun-feng Wang, Anil Kapur
• Localización: Diabetes care, ISSN-e 0149-5992, Vol. 36, Nº. 7, 2013, págs. 2038-2040
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • To evaluate the usefulness of a fasting plasma glucose (FPG) at 24-28 weeks' gestation to screen for gestational diabetes mellitus (GDM). The medical records and results of a 75-g 2-h oral glucose tolerance test (OGTT) of 24,854 pregnant women without known pre-GDM attending prenatal clinics in 15 hospitals in China were examined. FPG cutoff value of 5.1 mmol/L identified 3,149 (12.1%) pregnant women with GDM. FPG cutoff value of 4.4 mmol/L ruled out GDM in 15,369 (38.2%) women. With use of this cutoff point, 12.2% of patients with mild GDM will be missed. The positive predictive value is 0.322, and the negative predictive value is 0.928. FPG at 24-28 weeks' gestation could be used as a screening test to identify GDM patients in low-resource regions. Women with an FPG between ≥4.4 and ≤5.0 mmol/L would require a 75-g OGTT to diagnose GDM. This would help to avoid approximately one-half (50.3%) of the formal 75-g OGTTs in China.