Epstein–Barr virus-encoded small RNA 1 (EBER-1) could predict good prognosis in nasopharyngeal carcinoma
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Z. Zeng [1] ; S. Fan [1] ; X. Zhang [1] ; S. Li [1] ; M. Zhou [1] ; W. Xiong [1] ; M. Tan [1] ; W. Zhang [1] ; G. Li [1]
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[1] Central South University
Central South University
China
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- Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 18, Nº. 2 (February 2016), 2016, págs. 206-211
- Idioma: inglés
- Texto completo no disponible (Saber más ...)
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Resumen
Purpose EBER-1 (a non-coding RNA transcribed by EBV) expression was detected in most of Epstein–Barr virus (EBV)-positive nasopharyngeal carcinoma (NPC) patients. However, the relevance between EBER-1 expression and NPC clinical outcome has not been reported. This study aims to assess the possible correlations of EBER-1 expression and clinical parameters and its potential prognostic predictive ability in NPC patient’s outcomes.
Methods We examined EBER-1 mRNA expression in 301 NPC and 130 non-NPC tissues using in situ hybridization and did statistics.
Results EBER-1 expression was up-regulated in NPC tissues when compared to non-NPC tissues. A receiver operating characteristic analysis revealed that EBER-1 expression could distinguish non-cancerous patients from NPC patients (p < 0.001, sensitivity: 72.5 %, specificity: 83.5 %, AUC = 0.815). A survival analysis revealed that patients with high levels of EBER-1 expression had a significantly good prognosis (Disease-free survival: p = 0.019, overall survival: p = 0.006).
Conclusion These results indicated that EBER-1 expression is a potential prognosis factor of NPC and highly negative correlated with the progress of NPC.
