T cell metabolic fitness in antitumor immunity
- Autores: Peter J. Siska, Jeffrey C. Rathmell
- Localización: Trends in immunology, ISSN 1471-4906, Vol. 36, Nº. 4, 2015, págs. 257-264
- Idioma: inglés
- Enlaces
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Resumen
T cell metabolism has a central role in supporting and shaping immune responses and may have a key role in antitumor immunity. T cell metabolism is normally held under tight regulation in an immune response of glycolysis to promote effector T cell expansion and function. However, tumors may deplete nutrients, generate toxic products, or stimulate conserved negative feedback mechanisms, such as through Programmed Cell Death 1 (PD-1), to impair effector T cell nutrient uptake and metabolic fitness. In addition, regulatory T cells are favored in low glucose conditions and may inhibit antitumor immune responses. Here, we review how the tumor microenvironment modifies metabolic and functional pathways in T cells and how these changes may uncover new targets and challenges for cancer immunotherapy and treatment.
