Cholesterol Biosynthesis: Lanosterol to Cholesterol

• John M. Risley ^[1]
  1. [1] University of North Carolina at Charlotte

     University of North Carolina at Charlotte

     Estados Unidos

     
• Localización: Journal of chemical education, ISSN 0021-9584, Vol. 79, Nº 3, 2002, pág. 377
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Cholesterol is an important biochemical, medical, and commercial molecule. In the pathway for cholesterol biosynthesis, biochemistry textbooks discuss the synthesis of lanosterol from acetate in detail. However, the conversion of lanosterol to cholesterol is most often simply indicated as a multistep process, without elaboration. A pathway for the conversion of lanosterol to cholesterol, based on recent results from the primary research literature, is presented in this paper. Each reaction is discussed, the pathway is discussed within the context of general biochemical transformations, a summary of cholesterol homeostasis is presented, and enzyme deficiencies that give rise to diseases are given.