Resumen de Seom guidelines for the treatment of gastric cancer 2015

M. Martin Richard, Ana Custodio, Carlos García Girón, Cristina Grávalos Castro, Carlos Gómez Martín, P. Jiménez Fonseca, José Luis Manzano Mozo, Carles Pericay Pijaume, Fernando Rivera Herrero, Alfredo Carrato Mena

• Gastric cancer is the fourth cause of death by cancer in Spain and a significant medical problem. Molecular biology results evidence that gastroesophageal junction tumors and gastric cancer should be considered as two independent entities with a different prognosis and treatment approach. Endoscopic resection in very early tumors is feasible. Neoadjuvant and adjuvant therapy in locally advanced resectable tumor increase overall survival and should be considered standard treatments. In stage IV tumors, platinum–fluoropyrimidine-based schedule, with trastuzumab in HER2-overexpressed tumors, is the first-line treatment. Different therapies in second line have demonstrated in randomized studies their clear benefit in survival improvement.