Clinical guideline seom: hereditary colorectal cancer

• C. Guillén-Ponce ^[4] ; R. Serrano ^[5] ; A. B. Sánchez-Heras ^[1] ; A. Teulé ^[6] ; I. Chirivella ^[2] ; T. Martín ^[3] ; E. Martínez ^[7] ; R. Morales ^[8] ; L. Robles ^[9]
  1. [1] Hospital General Universitario de Elche

     Hospital General Universitario de Elche

     Elche, España

     
  2. [2] Hospital Clinico Universitario de Valencia

     Hospital Clinico Universitario de Valencia

     Valencia, España

     
  3. [3] Hospital Universitario de Salamanca

     Hospital Universitario de Salamanca

     Salamanca, España

     
  4. [4] Hospital Ramón y Cajal

     Hospital Ramón y Cajal

     Madrid, España

     
  5. [5] Hospital Reina Sofía

     Hospital Reina Sofía

     Tudela, España

     
  6. [6] Instituto Catalán de Oncología
  7. [7] Hospital Marqués de Valdecilla
  8. [8] Hospital La Mancha Centro
  9. [9] Hospital Doce de Octubre

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• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 17, Nº. 12, 2015, págs. 962-971
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Dialnet Métricas: 2 Citas
• Resumen

  • Genetic mutations have been identified as the cause of inherited cancer risk in some colon cancer; these mutations are estimated to account for only 5–6 % of colorectal cancer (CRC) cases overall. Up to 25–30 % of patients have a family history of CRC that suggests a hereditary component, common exposures among family members, or a combination of both. Cancers in people with a hereditary predisposition typically occur at an earlier age than in sporadic cases. A predisposition to CRC may include a predisposition to other cancers, such as endometrial cancer. We describe genetics, current diagnosis and management of CRC hereditary syndromes pointing to a multidisciplinary approach to achieve the best results in patients and family outcomes.