The Michael Reaction

• Thomas Poon ^[1] ; Bradford P. Mundy ^[1] ; Thomas W. Shattuck ^[1]
  1. [1] Colby College

     Colby College

     City of Waterville, Estados Unidos

     
• Localización: Journal of chemical education, ISSN 0021-9584, Vol. 79, Nº 2, 2002, pág. 264
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • A brief account of the Michael reaction is provided, illustrating its versatility as a topic in undergraduate chemistry courses. Included is a short biography of the reaction's namesake, examples of its use in organic synthesis, and its unique role in the defense mechanism of the bacterium Micromonospora echinospora. A computational rationale for the selectivity of 1,4 versus 1,2 addition of nucleophiles to α,β-unsaturated carbonyls is discussed and links to animations suitable for an introductory organic chemistry course are provided.