Contemporary Systemic Therapy for Urologic Malignancies in Geriatric Patients

• Autores: Bo Zhao, Petros D. Grivas
• Localización: Clinics in geriatric medicine, ISSN 0749-0690, Vol. 31, Nº. 4, 2015 (Ejemplar dedicado a: Geriatric Urology), págs. 645-665
• Idioma: inglés
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• Resumen

  • Current data on systemic therapy in geriatric populations with genitourinary malignancies are largely derived from retrospective analyses of prospectively conducted trials or retrospective reviews. Although extrapolation of these data to real-world patients should be cautious, patients aged 65 years or older with good functional status and minimal comorbidities seem to enjoy similar survival benefit from therapy as their younger counterparts. Chronologic age alone should generally not be used to guide management decisions. Comprehensive geriatric assessment tools and prospective studies in older adults integrating comprehensive geriatric assessment can shed light on the optimal management of urologic malignancies in this population.