Fertility Issues for Patients with Hypogonadotropic Causes of Delayed Puberty

• Autores: Jia Zhu, Yee-Ming Chan
• Localización: Endocrinology and metabolism clinics of North America, ISSN 0889-8529, Vol. 44, Nº. 4, 2015 (Ejemplar dedicado a: Reproductive Consequences of Pediatric Disease), págs. 821-834
• Idioma: inglés
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• Resumen

  • Delayed puberty presenting with low gonadotropins has multiple causes. Self-limited delay (constitutional delay) is generally considered benign, but adult height and bone mineral density may be compromised, and fertility has not been studied. Functional hypogonadotropic hypogonadism due to a stressor is thought to resolve with removal of the stressor, but reproductive endocrine dysfunction can sometimes persist. Most but not all patients with idiopathic hypogonadotropic hypogonadism, a typically long-lasting condition, can achieve fertility with exogenous hormone therapy. Future studies are needed to determine fertility outcomes in self-limited delayed puberty and to more clearly define prognostic factors for fertility in functional and idiopathic hypogonadotropic hypogonadism.