Modeling the Drug Discovery Process: The Isolation and Biological Testing of Eugenol from Clove Oil

• Patricia M. Smiley ^[2] ; William H. Miles ^[1]
  1. [1] Lafayette College

     Lafayette College

     City of Easton, Estados Unidos

     
  2. [2] Southern Lehigh High School, United States
• Localización: Journal of chemical education, ISSN 0021-9584, Vol. 79, Nº 1, 2002, pág. 90
• Idioma: inglés
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• Resumen

  • This experiment describes the isolation and biological testing of eugenol and neutral compounds from commercially available clove oil. By coupling the chemical separation of the components of clove oil (an experiment described in many introductory organic laboratory textbooks) with a simple antibiotic test, the students "discover" the biologically active compound in clove oil. This experiment models one of the primary methods used in the discovery of new pharmaceutical agents.