Solid-Phase Organic Synthesis and Combinatorial Chemistry

• George A. Truran ^[1] ; Karelle S. Aiken ^[1] ; Thomas R. Fleming ^[1] ; Peter J. Webb ^[1] ; J. Hodge Markgraf ^[1]
  1. [1] Williams College

     Williams College

     Town of Williamstown, Estados Unidos

     
• Localización: Journal of chemical education, ISSN 0021-9584, Vol. 79, Nº 1, 2002, pág. 85
• Idioma: inglés
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• Resumen

  • The principles and practice of solid-phase organic synthesis and combinatorial chemistry are utilized in a laboratory preparation of oligopeptides. A parallel synthesis scheme is used to generate a series of tripeptides. A divergent synthesis scheme is used to prepare two pentapeptides, one of which is leucine enkephalin, a neurotransmitter known to be an analgesic agent.