Effectiveness and toxicity of helical tomotherapy for patients with locally recurrent nasopharyngeal carcinoma

• Autores: F. Puebla, María Camino Urdiales, Raul Matute, I. Marrone, C. Iglesias Miguez, D. Sevillano, A. Sánchez Reyes, Eleonor Rivín del Campo
• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 17, Nº. 11, 2015, págs. 925-931
• Idioma: inglés
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• Resumen

  • Purpose We assessed therapeutic outcomes of reirradiation with helical tomotherapy (HT) for locoregional recurrent nasopharyngeal carcinoma (LRNPC) patients.

    Methods and materials Treatment outcomes were evaluated retrospectively in 17 consecutive LRNPC patients receiving HT between 2006 and 2012. Median age was 57 years and most patients (n = 13) were male. Simultaneous systemic therapy was applied in 5 patients. Initial treatment covered the gross tumor volume with a median dose of 70 Gy (60�81.6 Gy). Reirradiation was confined to the local relapse region with a median dose of 63 Gy (50�70.2 Gy), resulting in a median cumulative dose of 134 Gy (122�148.2 Gy). The median time interval between initial and subsequent treatment was 42 months (11�126).

    Results The median follow-up for the entire cohort was 23 and 35 months for survivors. Three patients (18 %) developed both local and distant recurrences and only one patient (6 %) suffered from isolated local recurrence. Two-year actuarial DFS and LC rates were 74 and 82 %, respectively. Two-year OS rate was 79 %. Acute and late grade 2 toxicities were observed in 8 patients (47 %). No patient experienced late grade =3 toxicity. Late toxicity included fibrosis of skin, hypoacusia, dysphagia, and xerostomia. Patients with higher Karnofsky performance status scores associated with a lower risk of mortality (HR 0.85, p = 0.015).

    Conclusion Reirradiation with HT in patients with LRNPC is feasible and yields encouraging results in terms of local control and overall survival with acceptable toxicity.