Mutual interaction between BCL6 and miRNAs contributing to the pathogenesis of various cancers

• Autores: Z. Wei, W. Gao, B. Ni, Y. Tian
• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 17, Nº. 11, 2015, págs. 841-846
• Idioma: inglés
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• Resumen

  • MicroRNA (miRNA), a class of non-protein-coding RNAs, plays a critical role in many cellular processes, such as invasion, proliferation and migration, and also function in disease pathology. The transcription factor and proto-oncogene B cell CLL/lymphoma 6 (BCL6) is aberrantly expressed in various cancers. An increasing body of evidence has demonstrated that miRNAs and BCL6 can target one another and mutually adjust their expression which are of great importance in the pathogenesis of various cancers. In this report, we summarize the mutual interaction between miRNAs and BCL6, which have been studied in cancers, highlighting their mechanisms and potential therapeutic targets in cancers.