Development of Adrenal Cortex Zonation

• Autores: Yewei Xing, Antonio M. Lerario, William Rainey, Gary D. Hammer
• Localización: Endocrinology and metabolism clinics of North America, ISSN 0889-8529, Vol. 44, Nº. 2, 2015 (Ejemplar dedicado a: Adrenal Cortical Neoplasia), págs. 243-274
• Idioma: inglés
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• Resumen

  • The human adult adrenal cortex is composed of the zona glomerulosa (zG), zona fasciculata (zF), and zona reticularis (zR), which are responsible for production of mineralocorticoids, glucocorticoids, and adrenal androgens, respectively. The final completion of cortical zonation in humans does not occur until puberty with the establishment of the zR and its production of adrenal androgens; a process called adrenarche. The maintenance of the adrenal cortex involves the centripetal displacement and differentiation of peripheral Sonic hedgehog–positive progenitors cells into zG cells that later transition to zF cells and subsequently zR cells.