Effect of Estrogen and Dietary Loading on Condylar Cartilage

• Autores: Marko Orajärvi, Shi-Bin Yu, Xiaodong Liu, Petri Tiilikainen, Meiqing Wang, Aune Raustia, Pertti Pirttiniemi
• Localización: Journal of Oral & Facial Pain and Headache, ISSN-e 2333-0376, ISSN 2333-0384, Vol. 26, Nº. 4, 2012, págs. 328-336
• Idioma: inglés
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  • Aims: To study the effect of estrogen deficiency and altered temporomandibular joint loading on the histomorphology of condylar cartilage and on the expression of types II and X collagen and matrix metalloproteinase-3 (MMP-3). Methods: Thirty-six female rats were divided into four groups: ovariectomized rats on a normal diet, nonovariectomized control rats on a normal diet, ovariectomized rats on a soft diet, and nonovariectomized control rats on a soft diet. Ovariectomy was performed at the age of 60 days. Repeated measures ANOVA was used to analyze the data. Results: The condylar cartilage in the ovariectomized normal diet group showed a significantly higher number of cells than in the nonovariectomized control rats (P < .001). The proportional amount of MMP-3 expression was significantly higher in the ovariectomized rats than in the nonovariectomized control rats in both diet groups (P < .001). The area covered by types II and X collagen was significantly higher in the experimental groups than in the control groups (P < .01). Conclusion: Condylar cartilage is sensitive to both estrogen level and dietary loading. J Orofac Pain 2012;26:328–336