Problems are an important part of teaching and important for achieving the creative education targets for graduates and upper-division undergraduates. Besides classical problems in textbooks, problems from recent research should be involved in class, too. This article reports how literature-based problems were incorporated in a scalable manner in a large-scale graduate course of organic structure analysis with widely varying levels of student preparedness at the University of Chinese Academy of Sciences. Two literature based problem designing cases were detailed, aiming at bringing possibilities and challenges to the students that are highly welcomed by them, and more such problems were provided further. The implications for both students and teachers were discussed to guide the future designing of more effective problems. These problems give students experience in modern scientific research in a large-scale class and build upon a habit that strongly emphasizes research-style thinking.
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