Dog breeding: Inherited pathology and pet trading

• Autores: Luis Vicente Monteagudo Ibáñez, María Teresa Tejedor Hernández, Alicia Uixerá, Olga Mitjana Nerin, María Victoria Falceto Recio, Cristina Bonastre Ráfales
• Localización: Veterinary Record, ISSN-e 2042-7670, Vol. 176, Nº. 12, 2015, págs. 315-316
• Idioma: inglés
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• Resumen

  • RECENTLY, two miniature schnauzer dogs affected by persistent Müllerian duct syndrome (PMDS) have been referred by independent local veterinary practitioners to the Faculty of Veterinary Sciences in Zaragoza, Spain. In light of the observed malformations in the genitalia, we performed DNA sequencing and verified that both dogs were homozygous carriers of the MISRII locus mutation, identified previously in the literature to be responsible for PMDS in this breed in the USA (Wu and others 2009). PMDS has been reported in miniature schnauzers in the Netherlands (Vegter and others 2010) and in Japan (Matsuu and others 2009), but in these cases the presence of this mutation was not verified.

    Since the odds for identical independent mutation events are virtually zero, a common genetic origin must be postulated, at least for the cases in the USA and in Spain for which DNA sequence information has been determined. Its recessive inheritance pattern, together with the fertility of some affected individuals, would have allowed the dissemination of PMDS in miniature schnauzers globally. Since we have been unable to trace the origin of the two dogs in this study (which were bought in pet shops by their owners), genetic control procedures cannot be implemented and we can only expect the occurrence of additional cases in the future.