Fluorescence-guided bone resection by using Visually Enhanced  Lesion Scope in diffuse chronic sclerosingosteomyelitis  of the mandible: clinical and pathological evaluation

Daigo Yoshiga; Masaaki Sasaguri; Kou Matsuo; Sei Yoshida; Masataka Uehara; Manabu Habu; Kazuya Haraguchi; Tatsurou Tanaka; Yasuhiro Morimoto; Izumi Yoshioka; Kazuhiro Tominaga

Ayuda

Fluorescence-guided bone resection by using Visually Enhanced Lesion Scope in diffuse chronic sclerosingosteomyelitis of the mandible: clinical and pathological evaluation

Daigo Yoshiga ^[1] ; Masaaki Sasaguri ^[1] ; Kou Matsuo ^[1] ; Sei Yoshida ^[1] ; Masataka Uehara ^[1] ; Manabu Habu ^[1] ; Kazuya Haraguchi ^[1] ; Tatsurou Tanaka ^[1] ; Yasuhiro Morimoto ^[1] ; Izumi Yoshioka ^[1] ; Kazuhiro Tominaga ^[1]
1. [1] Kyushu Dental University
  
  Kyushu Dental University
  
  Kokurakita Ku, Japón
Localización: Journal of Clinical and Experimental Dentistry, ISSN-e 1989-5488, Vol. 7, Nº. 4 (Octubre), 2015, págs. 548-551
Idioma: inglés
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Resumen
- Diffuse chronic sclerosingosteomyelitis (DCSO) is a refractory disease, becausethe etiology and pathogenesis remain poorly understood and to determine the border betweenunhealthy boneandhealthybone is difficult. However, progressive inflammation, clinical symptoms and a high recurrence rate of DCSO were the reasons for surgical treatment. We report a case of a 66-year old woman with DCSO of the right side of mandible who was treated with hemimandibulectomy and simultaneous reconstruction by vascularized free fibula flap. After preoperative administration of minocycline for 1 month, the bone fluorescence was successfully monitored by using a Visually Enhanced Lesion Scope (VELscope®). Intraoperatively, we could determine the resection boundaries. We investigated the clinical and histopathological findings. The fluorescence findings were well correlated with histopathological findings. Using a VELscope®was handy and useful to determine the border between DCSO lesion andhealthybone.
  
  The free fibula flap under the minocycline-derived bone fluorescence by using a VELscope®offered a good quality of mandibular bone and the successful management of an advanced and refractory DCSO.