Metallothionein immunoexpression in non-syndromic and syndromic keratocystic odontogenic tumour

• Aline-Cristina-Batista-Rodrigues Johann ^[1] ; Patrícia-Carlos Caldeira ^[2] ; Marcelo-Vidigal Caliari ^[2] ; Ricardo-Santiago Gomez ^[2] ; Maria-Cássia-Ferreira Aguiar ^[2] ; Ricardo-Alves Mesquita ^[2]
  1. [1] Pontifícia Universidade Católica do Paraná

     Pontifícia Universidade Católica do Paraná

     Brasil

     
  2. [2] Universidade Federal de Minas Gerais

     Universidade Federal de Minas Gerais

     Brasil

     
• Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 20, Nº. 4 (julio), 2015
• Idioma: inglés
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• Resumen

  • Background: To commpare the metallothionein (MT) immunoexpression in non-syndromic and syndromic keratocystic odontogenic tumour (KOT), to correlate MT with cellular proliferation, and to evaluate the influence of inflammation in MT.

    Material and Methods: Fourteen cases of KOT were submitted to imm unohistochemistry for MT and Ki-67 analysis.

    The lesions were grouped according to their grade of inflammation, and statistical analysis was performed.

    Results: MT was higher in non-syndromic KOT than in syndromic KOT (p<0.05). No statistical difference in Ki- 67 could be identified; however, an inverse correlation was observed between MT and Ki-67 in both lesions. When analysing inflammation, non-syndromic KOT showed no differences in either MT or Ki-67.

    Conclusions: The MT imm unophenotype of syndromic KOT was different from non-syndromic KOT. MT might not be involved in the proliferation control of both KOT. MT and Ki-67 imm unoexp ressions proved to be unaffected by inflammation in non-syndromic KOT.