E-cadherin, ß-catenin, and a2ß1 and a3ß1 integrin expression in primary oral squamous cell carcinoma and its regional metastasi

• Autores: Mariana Quirino Silveira Soares, Juliana Andrade Mendonça, Marília Oliveira Morais, Claudio Rodrigues Leles, Aline Carvalho Batista, Elismauro Francisco Mendonça
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 30, Nº. 10, 2015, págs. 1213-1222
• Idioma: inglés
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• Resumen

  • To investigate E-cadherin, ß-catenin, and a2ß1 and a3ß1 integrins in 40 samples of non-metastatic and metastatic oral squamous cell carcinoma (OSCC) with positive cervical lymph nodes (LN). Immunohistochemistry was used to evaluate expression in the lesion center (LC) and invasive tumor front (ITF) of non-metastatic (n=18) and metastatic (n=22) OSCC and in the LN on the metastatic neoplastic cells (MNC; n=22). In metastatic OSCC, E-cadherin and ß-catenin presented significantly lower cytoplasmic membrane expression in the ITF and MNC when compared to the LC and lower cytoplasmic expression in MNC when compared to the LC and ITF (p<0.05). Integrins a2ß1 and a3ß1 showed high cytoplasmic expression in the LC, ITF and MNC (p>0.05). A positive correlation was observed between E-cadherin cytoplasmic expression and a2ß1 (p=0.860) and a3ß1 (p=0.975) expression. When comparing the primary sites of metastatic and non-metastatic disease, ß-catenin presented lower cytoplasmic membrane (p=0.013) expression in metastatic OSCC. E-cadherin presented low expression and the integrins high expression in both groups. Abnormal expression of ß-catenin and E-cadherin associated with high expression of a2ß1 and a3ß1 integrins contribute to LN metastasis in OSCC